Gap19 acetate(1507930-57-5,free)

Research use only, not for human use.

Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.Hemichannel inhibition is due to the binding of Gap19 to the C-terminus (CT) thereby preventing intramolecular CT-CL interactions.?The peptide inhibited Cx43 hemichannel unitary currents in both HeLa cells exogenously expressing Cx43 and acutely isolated pig ventricular cardiomyocytes.?

Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.Hemichannel inhibition is due to the binding of Gap19 to the C-terminus (CT) thereby preventing intramolecular CT-CL interactions.?The peptide inhibited Cx43 hemichannel unitary currents in both HeLa cells exogenously expressing Cx43 and acutely isolated pig ventricular cardiomyocytes.?Treatment with Gap19 prevented metabolic inhibition-enhanced hemichannel openings, protected cardiomyocytes against volume overload and cell death following ischemia/reperfusion in vitro and modestly decreased the infarct size after myocardial ischemia/reperfusion in mice in vivo.?

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Others

Other Targets

Cx43

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1507930-57-5

1161.44

C55H96N14O13

>98% (HPLC)

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CC[C@]([H])(C)[C@@]([H])(/C(O)=N/[C@@]([H])(CCCCN)/C(O)=N/[C@@]([H])(CCCCN)/C(O)=N/[C@@]([H])(CC1=CC=CC=C1)/C(O)=N/[C@@]([H])(CCCCN)C(O)=O)/N=C([C@]([H])(CCC(O)=O)/N=C([C@]([H])([C@@]([H])(C)CC)/N=C([C@]([H])(CCC(O)=N)/N=C([C@]([H])(CCCCN)N)\O)\O)\O)\O.CC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years